Solubility is one of the most important parameter to achieve desired concentration of the drug in systemic circulation for pharmacological response to be shown. Poorly water soluble drug often require high dose in order to reach therapeutic plasma concentration after oral administration. To the aqueous solubility can help to increase the efficacy and reduce the side effects of the drug. For improving the oral bioavailability of the drug various technique are used. This review article thus begins with discussion regarding the traditional approaches to drug solubilization include solid dispersion, Complexation, and physical mixture.
Loading....